Pit-1 and hypopituitarism.
Trends Endocrinol Metab
; 4(3): 81-5, 1993 Apr.
Article
em En
| MEDLINE
| ID: mdl-18407138
ABSTRACT
The story of Pit-1 and hypopituitarism in humans provides an excellent example of pleiotrophism or multiple phenotypic effects resulting from a single genetic alteration. It shows how defects in this single gene cause the absence o f several pituitary hormones. Three recent articles reviewed here provide examples of different mutations in this homeobox gene encoding a transcriptional activation protein that is vital to the embryologic development, survival, and differentiated function of somatotropes, lactotropes, and thyrotropes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Revista:
Trends Endocrinol Metab
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
1993
Tipo de documento:
Article
País de afiliação:
Estados Unidos