Corymbones A and B, phloroglucinols with thyrotropin releasing hormone receptor 2 binding affinity from the flowers of Corymbia peltata.
J Nat Prod
; 71(5): 881-3, 2008 May.
Article
em En
| MEDLINE
| ID: mdl-18412395
ABSTRACT
High-throughput screeing of a plant and marine invertebrate extract library to find natural products with rat thytotropin releasing hormone receptor 2 binding affinity led to the isolation of two new active acylphloroglucinols, corymbones A and B (1 and 2) from flowers of the Queensland tree Corymbia peltata. Their structures were assigned from interpretation of 2D NMR and high-resolution ESIMS data. Compounds 1 and 2 showed rat TRH receptor 2 binding affinity with IC 50 values of 23 and 19 microM, respectively.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Floroglucinol
/
Plantas Medicinais
/
Receptores do Hormônio Liberador da Tireotropina
/
Myrtaceae
Limite:
Animals
País/Região como assunto:
Oceania
Idioma:
En
Revista:
J Nat Prod
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Austrália