A TRIFfic perspective on acute lung injury.

Martin, Thomas R; Wurfel, Mark M

Martin, Thomas R; Wurfel, Mark M.

Afiliação

Martin TR; The Medical Research Service of the VA Puget Sound Health Care System and the Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA 98108, USA. trmartin@u.washington.edu

Cell ; 133(2): 208-10, 2008 Apr 18.

Article em En | MEDLINE | ID: mdl-18423191

ABSTRACT

ABSTRACT

Acute lung injury (ALI) is a leading cause of death in people infected with H5N1 avian influenza virus or the SARS-coronavirus. Imai et al. (2008) now report that ALI is triggered by the signaling of oxidized phospholipids through Toll-like receptor 4 (TLR4) and the adaptor protein TRIF. These findings provide insight into the molecular pathogenesis of ALI, a condition for which treatment options are currently very limited.

Assuntos

Proteínas Adaptadoras de Transporte Vesicular/metabolismo; Síndrome do Desconforto Respiratório/metabolismo; Receptor 4 Toll-Like/metabolismo; Animais; Humanos; Camundongos; Estresse Oxidativo; Fosfolipídeos/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndrome do Desconforto Respiratório / Proteínas Adaptadoras de Transporte Vesicular / Receptor 4 Toll-Like Limite: Animals / Humans Idioma: En Revista: Cell Ano de publicação: 2008 Tipo de documento: Article País de afiliação: Estados Unidos

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