Virus-specific cytotoxic lymphocyte response in a neurotropic murine leukemia virus infection.
J Neuroimmunol
; 31(1): 9-17, 1991 Jan.
Article
em En
| MEDLINE
| ID: mdl-1845770
ABSTRACT
NFS/N mice infected with neurotropic Cas-Br-M murine leukemia virus (MuLV) at 21 days of age were resistant to neurologic disease and demonstrated MuLV-specific cytotoxic T lymphocyte (CTL) activity in spleen cells after in vitro stimulation. NFS/N mice infected with Cas-Br-M MuLV at 2 days of age failed to generate a significant MuLV-specific CTL response and developed neurologic disease 5-8 weeks later. Protection from neurologic disease transferred with fewer in vitro stimulated immune spleen cells than immune T cells from NFS/N mice infected with Cas-Br-M MuLV at 21 days of age. Cas-Br-M MuLV-specific CTL may play an important role in resistance to the paralytic effects of Cas-Br-M MuLV infection by affecting virus dissemination to the central nervous system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T Citotóxicos
/
Vírus da Leucemia Murina
Limite:
Animals
Idioma:
En
Revista:
J Neuroimmunol
Ano de publicação:
1991
Tipo de documento:
Article