MMP-2 geno-phenotype is prognostic for colorectal cancer survival, whereas MMP-9 is not.
Br J Cancer
; 98(11): 1820-3, 2008 Jun 03.
Article
em En
| MEDLINE
| ID: mdl-18506186
ABSTRACT
The prognostic significance of single-nucleotide polymorphisms (SNPs) and tumour protein levels of MMP-2 and MMP-9 was evaluated in 215 colorectal cancer patients. Single-nucleotide polymorphism MMP-2(-1306T) and high MMP-2 levels were significantly associated with worse survival. Extreme tumour MMP-9 levels were associated with poor prognosis but SNP MMP-9(-1562C>T) was not. Tumour MMP levels were not determined by their SNP genotypes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Colorretais
/
Metaloproteinase 2 da Matriz
/
Metaloproteinase 9 da Matriz
/
Polimorfismo de Nucleotídeo Único
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Br J Cancer
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Holanda