Human metapneumovirus small hydrophobic protein inhibits NF-kappaB transcriptional activity.
J Virol
; 82(16): 8224-9, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18550666
ABSTRACT
Human metapneumovirus, a leading cause of respiratory tract infections in infants, encodes a small hydrophobic (SH) protein of unknown function. In this study, we showed that infection of airway epithelial cells or mice with recombinant human metapneumovirus lacking SH expression (rhMPV-DeltaSH) enhanced secretion of proinflammatory mediators, including interleukin 6 (IL-6) and IL-8, encoded by two NF-kB-dependent genes, compared to infection with wild-type rhMPV. RhMPV-DeltaSH infection resulted in enhanced NF-kB-dependent gene transcription and in increased levels of phosphorylated and acetylated NF-kB without affecting its nuclear translocation, identifying a possible novel mechanism by which paramyxovirus SH proteins modulate NF-kB activation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Transcrição Gênica
/
Regulação Viral da Expressão Gênica
/
Proteínas Oncogênicas de Retroviridae
/
NF-kappa B
/
Metapneumovirus
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
J Virol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Estados Unidos