Potential relationship between Helicobacter pylori and ischemic heart disease: any pathogenic model?
Panminerva Med
; 50(2): 161-3, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18607339
ABSTRACT
Helicobacter pylori (H.pylori), causal agent of several gastroduodenal diseases, has been involved in diverse aspects of many extragastric manifestations, including ischemic heart disease (IHD). The present paper focuses on the potential pathogenic mechanisms relating H. pylori to IHD. Since H. pylori DNA has been detected in the coronary arteries only in sporadic occasions, and considering that long-term inflammation might raise cytokine levels in the bloodstream, an indirect pathway is more plausible. Moreover, the evidence that some strains of H. pylori induce platelet aggregation supports a role in the acute phase of IHD. In conclusion, because IHD is a multifactorial disease, it is evident that H. pylori is not the only cause. Thus, the definition of H. pylori or other infectious agents as culprits requires a multidisciplinary approach.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Helicobacter pylori
/
Infecções por Helicobacter
/
Isquemia Miocárdica
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Panminerva Med
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Itália