IAPs as therapeutic targets in haematological malignancies.
Expert Opin Ther Targets
; 12(8): 981-93, 2008 Aug.
Article
em En
| MEDLINE
| ID: mdl-18620520
ABSTRACT
BACKGROUND:
Regulation of apoptosis is fundamental to maintain the balance between cell survival and cell death. Disruption of this process may have severe consequences, contributing to carcinogenesis. Therapeutic targeting of the proteins that control apoptosis may therefore be used in the treatment of various types of cancer.OBJECTIVE:
We address whether regulators of apoptosis could be suitable targets for the treatment of haematological cancers.METHODS:
We focus on the emerging role of inhibitor of apoptosis (IAP) proteins in cancer, their modulators and the possibility of therapeutically targeting these proteins in haematological cancer. RESULTS/CONCLUSION:
IAPs have emerged as an important novel class of intracellular proteins that regulate apoptosis. Various compounds have been described that may be used to modulate the activity of IAPs, which opens the way to therapeutically targeting these proteins in cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hematológicas
/
Proteínas Inibidoras de Apoptose
Limite:
Humans
Idioma:
En
Revista:
Expert Opin Ther Targets
Assunto da revista:
TERAPEUTICA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Holanda