Your browser doesn't support javascript.
loading
Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.
Mansouri, Roxane M; Baugé, Eric; Gervois, Philippe; Fruchart-Najib, Jamila; Fiévet, Catherine; Staels, Bart; Fruchart, Jean-Charles.
Afiliação
  • Mansouri RM; Inserm, U545, Institut Pasteur de Lille, Lille F-59019, France.
Circ Res ; 103(5): 450-3, 2008 Aug 29.
Article em En | MEDLINE | ID: mdl-18658049
Hypertriglyceridemia is an independent risk factor for coronary artery disease. Because apolipoprotein (Apo)A5 regulates plasma triglyceride levels, we investigated the impact of human (h)ApoA5 on atherogenesis. The influence of hApoA5 transgenic expression was studied in the ApoE2 knock-in mouse model of mixed dyslipidemia. Our results demonstrate that hApoA5 lowers plasma triglyceride levels in Western diet-fed ApoE2 knock-in mice. Moreover, atherosclerotic lesion development was significantly decreased in the hApoA5 transgenic mice. Finally, pharmacologic activation of hApoA5 expression by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate resulted in an enhanced atheroprotection. These results identify an atheroprotective role of hApoA5 in a mouse model of mixed dyslipidemia.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas A / Triglicerídeos / Aterosclerose / Dislipidemias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Circ Res Ano de publicação: 2008 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Apolipoproteínas A / Triglicerídeos / Aterosclerose / Dislipidemias Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Female / Humans / Male Idioma: En Revista: Circ Res Ano de publicação: 2008 Tipo de documento: Article País de afiliação: França