Genotoxic action of fungicide Conan 5FL (hexaconazole) on mammalian cells in vivo and in vitro.
Genetika
; 44(3): 323-8, 2008 Mar.
Article
em En
| MEDLINE
| ID: mdl-18664135
ABSTRACT
The genotoxic effects of fungicide Conan 5FL (containing 50 g/L hexaconazole) in mouse bone-marrow cells and human lymphocytes have been evaluated. Three different concentrations of Conan 5FL (17.50, 35.00 and 70.00 microg/mL for human lymphocytes and 17.50, 35.00 and 70.00 mg/kg for mouse bone marrow cells) were studied. Conan 5FL induced significant increases (except 17.50 mg/kg for mouse bone marrow) in the frequency of chromosomal aberrations (CAs) in both test systems. This fungicide caused structural and numerical abnormalities in both mammalian cells. These are sister chromatid union, chromatid and chromosome breaks, fragments, dicentric and ring chromosomes, and polyploidy. Significant increase was found in induction and in minimum-maximum numbers of sister chromatid exchanges (SCEs) at all treatments compared with the negative control. Conan 5FL did not affect the replication index (RI) in human lymphocyte cultures, however, it significantly decreased the mitotic index (MI) in all treatment concentrations in both test systems. Using of Conan 5FL should be reconsidered due to its possible cytotoxic, clastogenic and mutagenic effects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Triazóis
/
Aberrações Cromossômicas
/
Fungicidas Industriais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Genetika
Ano de publicação:
2008
Tipo de documento:
Article