Modern techniques for pituitary radiotherapy.
Rev Endocr Metab Disord
; 10(2): 135-44, 2009 Jun.
Article
em En
| MEDLINE
| ID: mdl-18787957
ABSTRACT
Radiotherapy (RT) remains an effective treatment for residual or recurrent pituitary adenomas with excellent rates of tumour control and normalisation of excess hormone secretion. The main late toxicity is hypopituitarism other side effects are rare. We discuss technical developments in the delivery of radiotherapy (stereotactic conformal radiotherapy (SCRT) and stereotactic radiosurgery (SRS)), all aiming to reduce the amount of normal brain receiving significant doses of radiation. We provide a comprehensive review of published data on outcome of conventional fractionated radiotherapy and modern RT techniques. SCRT is a suitable treatment technique for all sizes of pituitary adenoma and efficacy is comparable to conventional RT; the lack of long term follow up means that currently there is no information on potential reduction in the incidence of late radiation induced toxicity. Single fraction SRS can only be safely delivered to small tumours away from critical structures. There is no evidence that it produces faster decline of elevated hormone levels than fractionated treatment and is not associated with lesser morbidity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Hipofisárias
/
Radioterapia
Limite:
Humans
Idioma:
En
Revista:
Rev Endocr Metab Disord
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido