Transgenic expression of cyclooxygenase-2 in mouse intestine epithelium is insufficient to initiate tumorigenesis but promotes tumor progression.
Cancer Lett
; 273(2): 225-32, 2009 Jan 18.
Article
em En
| MEDLINE
| ID: mdl-18790560
ABSTRACT
We generated mice expressing a COX-2 transgene in colon epithelium and found that they did not develop spontaneous colon tumors. But when treated with azoxymethane, a colon carcinogen, COX-2 mice had a higher tumor load compared to wild-type mice. There was no change in the number of pre-neoplastic lesions, indicating that COX-2 does not affect tumor initiation. Tumors in the COX-2 transgenic mice had higher levels of phosphorylated epidermal growth factor receptor and Akt compared to wild-type mice. Collectively, our data indicate that COX-2 promotes colon tumor progression, but not initiation, and it does so, in part, by activating EGFR and Akt signaling pathways.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Regulação Neoplásica da Expressão Gênica
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Transgenes
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Epitélio
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Ciclo-Oxigenase 2
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Proteínas Proto-Oncogênicas c-akt
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Receptores ErbB
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Mucosa Intestinal
Limite:
Animals
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Female
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Humans
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Male
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos