Hypothyroidism after primary surgical treatment for laryngeal and hypopharyngeal cancer.
Kulak Burun Bogaz Ihtis Derg
; 18(3): 125-30, 2008.
Article
em En
| MEDLINE
| ID: mdl-18984992
ABSTRACT
OBJECTIVES:
We investigated the incidence of hypothyroidism after treatment of laryngeal or hypopharyngeal cancer (LHC), and evaluated its relationship with treatment modalities. PATIENTS ANDMETHODS:
Thyroid functions of 42 patients (41 males, 1 female; mean age 58 years; range 35 to 81 years) undergoing surgical treatment with (74%) or without adjuvant radiotherapy for LHC were prospectively evaluated preoperatively, on the 15th day, and in the sixth month postoperatively. The results were compared in relation to the treatment methods employed.RESULTS:
The overall incidence of post-treatment hypothyroidism was 23.8%. Five patients had hypothyroidism in the early postoperative period, and this number increased to 10 after six months. All patients with hypothyroidism had undergone total laryngectomy with bilateral neck dissection, followed by radiotherapy. A significantly higher incidence of hypothyroidism was associated with total laryngectomy, bilateral neck dissection, level VI dissection, partial or bilateral thyroidectomy, adjuvant radiotherapy, and upper mediastinal radiotherapy.CONCLUSION:
The incidence of post-treatment hypothyroidism is not rare in LHC patients, requiring long-term monitoring of thyroid functions to prevent associated morbidities.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Complicações Pós-Operatórias
/
Tireoidectomia
/
Neoplasias Hipofaríngeas
/
Neoplasias Laríngeas
/
Hipotireoidismo
/
Laringectomia
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Asia
Idioma:
En
Revista:
Kulak Burun Bogaz Ihtis Derg
Assunto da revista:
AUDIOLOGIA
/
OTORRINOLARINGOLOGIA
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Turquia