Mechanism of T-cell activation by mycobacterial antigens in inflammatory synovitis.
Scand J Immunol
; 33(3): 253-60, 1991 Mar.
Article
em En
| MEDLINE
| ID: mdl-1901422
ABSTRACT
Earlier studies demonstrated enhanced proliferative responses to an acetone precipitable Mycobacterium tuberculosis (AP-MT) antigenic complex by T lymphocytes from the synovial fluid, compared with the peripheral blood, of patients with inflammatory synovitis, including rheumatoid arthritis. In contrast, decreased proliferation and interleukin 2 (IL-2) production in response to mitogens by synovial fluid lymphocytes from patients with rheumatoid arthritis has been demonstrated. In order to determine if IL-2 was produced in response to AP-MT, the peripheral blood and synovial fluid of patients with inflammatory arthritis were analysed by measuring proliferation and IL-2 production in response to AP-MT and tetanus toxoid. A reduction of IL-2 production relative to proliferation was observed in some, but not all, synovial fluids of patients who responded to the AP-MT. Nevertheless, antibodies to IL-2 as well as interleukin 4 (IL-4), significantly inhibited proliferation of synovial fluid lymphocytes by AP-MT. There was no inhibition by antibodies to interleukin 6 (IL-6). We conclude that AP-MT induced proliferation by synovial fluid lymphocytes is mediated by both IL-2 and IL-4.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinovite
/
Ativação Linfocitária
/
Linfócitos T
/
Mycobacterium tuberculosis
/
Antígenos de Bactérias
Limite:
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Scand J Immunol
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Israel