Promiscuous interaction between gold-specific T cells and APCs in gold allergy.
J Immunol
; 181(11): 8096-102, 2008 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-19018002
ABSTRACT
Gold compounds clinically used as immunomodulators have high potential to evoke hypersensitivity reactions as an adverse effect. To explore the mechanism of gold allergy, we immunologically characterized T cells infiltrating skin rashes and generated 44 gold-specific T cell clones and lines from a rheumatoid arthritis patient who developed skin rashes and systemic symptoms after gold treatment. CD4(+) and CD8(+) cells predominantly infiltrating the skin rashes and some of the T cell clones and lines shared common Vbetas. These cells exhibited Th0-like, Th2-like, and Tc1-like cytokine profiles, and showed chemotactic activities for thymus and activation-regulated chemokine and IFN-gamma-inducible protein-10 corresponding to the cytokine profiles. T cell recognition of gold consisted of MHC-restricted and MHC-independent pathways. Blocking studies with anti-MHC Abs indicated that the groove of MHC in APCs, where Ags should ordinarily be settled, did not serve as a conjugating site of gold for these T cells in certain cases. These observations raise the possibility that gold-specific CD4(+) and CD8(+) T cells and APCs promiscuously interact under stimulation with gold, resulting in various clinical manifestations in gold allergy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Linfócitos T Citotóxicos
/
Comunicação Celular
/
Tiomalato Sódico de Ouro
/
Células Th2
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Antirreumáticos
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Hipersensibilidade a Drogas
/
Células Apresentadoras de Antígenos
Limite:
Aged
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Female
/
Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Immunol
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Japão