In situ immune responses to interstitial pneumonitis in human visceral leishmaniasis.
Parasite Immunol
; 31(2): 98-103, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19149777
ABSTRACT
Lung disease during active human visceral leishmaniasis is frequently reported. As such, studies have associated pulmonary symptoms to interstitial pneumonitis with a mononuclear infiltrate. However, the immune response in this condition has never been described before. The aim of this study was to determine the immunophenotypic pattern and cytokine profile of lung involvement (IPL) in human visceral leishmaniasis. Quantitative methods of analysis were performed using immunohistochemistry, and were compared with a control group of normal lung. Interstitial macrophages and cd8 cells were increased in IPL, and IL-4 as well as TNF-alpha displayed increased expression when compared to the control group. This inflammatory process with a Th2 pattern, as suggested by increased IL-4 and low IFN-gamma expression, is consistent with the immune response in other organs of visceral leishmaniasis. The microenvironment of the immune response in this condition is associated with lung disease in patients with interstitial pneumonitis related to visceral leishmaniasis, increasing the chance of bacterial infection.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Pulmonares Intersticiais
/
Leishmaniose Visceral
/
Pneumopatias Parasitárias
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Parasite Immunol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Brasil