Development of alpha-tocopherol acetate nanoparticles: influence of preparative processes.
Drug Dev Ind Pharm
; 35(2): 216-23, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19169943
ABSTRACT
We studied different methods of preparing alpha-tocopherol acetate (ATA) nanoparticles, which are to be used in targeting the lungs as aerosols in order to prevent cigarette smoke toxicity. Poly-(lactide) nanoparticles were prepared using nanoprecipitation and solvent evaporation techniques, which produced, respectively, too small and too large nanoparticles to be aerosolized. The emulsification-diffusion method produced 2 months stable nanoparticles with a size between (500-700 nm). Increasing ATA concentration (1-7 mg/mL) induced a decrease in the association rate (97-93%) and in the adsorbed ATA rate (7-4.5%), which was associated with variations of Zeta potentials (-27.5 to -24.3 mV) and decrease in polymeric wall thickness and density.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistemas de Liberação de Medicamentos
/
Alfa-Tocoferol
/
Nanopartículas
/
Antioxidantes
Idioma:
En
Revista:
Drug Dev Ind Pharm
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França