Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation.
Cancer Invest
; 27(3): 251-6, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19194824
ABSTRACT
Thymosin beta-10 (T beta 10) has been shown to be associated with several cancers; however, its role in pancreatic cancer is not understood. The expression of T beta 10 was determined by immunohistochemistry and real-time polymerase chain reaction. The phosphorylation of JNK and the cytokine secretion was determined by using the Bio-Plex phosphoprotein and cytokines assays. Pancreatic cancer tissues and cells expressed higher amounts of T beta 10 than normal surrounding tissues and human pancreatic duct epithelial cells. Exogenous T beta 10 caused the phosphorylation of JNK and increased the secretion of cytokines interleukin (IL)-7 and IL-8 in BxPC-3 cells. T beta 10 might be a promising marker and a novel therapeutic target for pancreatic cancer.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Timosina
/
Proteínas Quinases JNK Ativadas por Mitógeno
Limite:
Humans
Idioma:
En
Revista:
Cancer Invest
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos