Three siderophores from one bacterial enzymatic assembly line.
J Am Chem Soc
; 131(14): 5056-7, 2009 Apr 15.
Article
em En
| MEDLINE
| ID: mdl-19320483
ABSTRACT
Siderophores play a vital role in the survival of bacteria, as they facilitate the transport of iron in low-concentration environments. Nature employs a variety of coordinating functional groups in siderophore scaffolds as a way of creating structural diversity. We have successfully shown that the pseudomonine synthetase can produce three distinct siderophore natural products and five siderophore-like compounds. The in vitro enzymatic production of acinetobactin has prompted a revision of the reported structure from an oxazoline to an isoxazolidinone. Our results reveal the inherent flexibility of the pseudomonine synthetase and thus provide insight into the evolution of siderophore biosynthetic gene clusters in bacteria.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pseudomonas
/
Proteínas de Bactérias
/
Sideróforos
/
Ligases
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos