Bullous pemphigoid: a prototypical antibody-mediated organ-specific autoimmune disease.
J Invest Dermatol
; 129(4): 822-4, 2009 Apr.
Article
em En
| MEDLINE
| ID: mdl-19322161
ABSTRACT
Bullous pemphigoid (BP) is a prototypical organ-specific autoimmune disease. Autoantibodies unfold their blister-inducing potential by triggering an Fcgamma-dependent inflammatory reaction. The study by Iwata et al. in this issue provides the first direct evidence that IgG autoantibodies from BP patients may also weaken cell-matrix adhesion by depleting BP180/type XVII collagen from cultured keratinocytes. These novel findings shed new light on additional mechanisms of blister formation in pemphigoid diseases and open the way for further informative studies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Autoantígenos
/
Imunoglobulina G
/
Penfigoide Bolhoso
/
Colágenos não Fibrilares
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
J Invest Dermatol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha