Wilms tumour and paternal occupation: an analysis of data from the National Registry of Childhood Tumours.
Pediatr Blood Cancer
; 53(1): 28-32, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19343797
ABSTRACT
BACKGROUND:
Wilms tumour is an embryonal malignant tumour that accounts for 90% of childhood kidney cancers. Parental occupational exposure has been hypothesised to be a cause of childhood Wilms tumour, in particular exposure to pesticides. However, the findings are inconsistent. PROCEDURE We have examined the association between paternal occupational exposures and Wilms tumour using birth registration data for cases (n = 2568) from the National Registry of Childhood Tumours (NRCT) and matched controls (n = 2,568) drawn from the general population of Great Britain. Paternal occupation, as recorded at the time of birth, was used to infer "occupational exposure" using a previously defined occupational exposure classification scheme. Odds ratios and 95% confidence intervals were generated using conditional logistic regression with exact methods to estimate the association between each paternal occupational exposure group and childhood Wilms tumour.RESULTS:
All odds ratios were close to 1.00 and no statistically significant associations were observed.CONCLUSION:
The results of this study failed to support any of the previously identified associations between paternal occupation and childhood Wilms tumour.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Efeitos Tardios da Exposição Pré-Natal
/
Exposição Ocupacional
/
Tumor de Wilms
/
Exposição Paterna
/
Neoplasias Renais
/
Ocupações
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Revista:
Pediatr Blood Cancer
Assunto da revista:
HEMATOLOGIA
/
NEOPLASIAS
/
PEDIATRIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido