Vitamin and micronutrient concentrations in cyclosporine-induced renal tumor from diabetic rats.

Reddi, A S; Jyothirmayi, G N; DeAngelis, B; Kabaria, V; Frank, O; Baker, H

Reddi, A S; Jyothirmayi, G N; DeAngelis, B; Kabaria, V; Frank, O; Baker, H.

Afiliação

Reddi AS; Department of Medicine, UMDNJ-New Jersey Medical School, Newark 07103.

Life Sci ; 49(21): 1531-7, 1991.

Article em En | MEDLINE | ID: mdl-1943457

ABSTRACT

ABSTRACT

Concentrations of vitamins, biopterin, free inositol and acid-soluble carnitine were determined in cyclosporine A induced renal adenocarcinoma and uninvaded renal tissue from streptozotocin diabetic rats. Vitamin B6, thiamin, riboflavin, nicotinate, free inositol and acid-soluble carnitine were significantly decreased in tumor than nontumor tissue. Concentrations of folic acid, B12, biotin, pantothenate and biopterin were similar in both tissues. These studies suggest that renal adenocarcinoma affects concentrations of only certain vitamins and micronutrients.

Assuntos

Adenocarcinoma/metabolismo; Neoplasias Renais/metabolismo; Rim/química; Vitaminas/análise; Adenocarcinoma/induzido quimicamente; Adenocarcinoma/patologia; Animais; Biopterinas/análise; Glicemia/análise; Carnitina/análise; Ciclosporina/toxicidade; Diabetes Mellitus Experimental/metabolismo; Inositol/análise; Neoplasias Renais/induzido quimicamente; Neoplasias Renais/patologia; Masculino; Ratos; Ratos Endogâmicos

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Vitaminas / Adenocarcinoma / Rim / Neoplasias Renais Limite: Animals Idioma: En Revista: Life Sci Ano de publicação: 1991 Tipo de documento: Article

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