Innate immune receptors on neutrophils and their role in chronic lung disease.
Eur J Clin Invest
; 39(7): 535-47, 2009 Jul.
Article
em En
| MEDLINE
| ID: mdl-19453653
ABSTRACT
Neutrophils, the prototypic cells of the innate immune system, are recruited to infected sites to protect the human body from invading pathogens. To accomplish this function, neutrophils sense pathogens and endogenous damage-associated molecules via innate immune receptors, such as Toll-like receptors (TLRs) and other pattern recognition receptors. This defence function is essential for the pulmonary microenvironment where the host is faced with millions of particles and pathogens inhaled daily. Chronic lung diseases, such as cystic fibrosis or chronic obstructive pulmonary disease are characterized by a neutrophil accumulation and chronic bacterial colonization of the airways. Consequently, insights into the role of TLRs on neutrophils in chronic lung diseases are of high relevance for further diagnostic and therapeutic approaches. Here we summarize and discuss recent advances in the expression, regulation and functional role of TLRs on neutrophils in chronic lung diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Receptores Imunológicos
/
Receptores Toll-Like
/
Pneumopatias
/
Neutrófilos
Limite:
Humans
Idioma:
En
Revista:
Eur J Clin Invest
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Alemanha