A microfluidic mixing system for single-molecule measurements.
Rev Sci Instrum
; 80(5): 055105, 2009 May.
Article
em En
| MEDLINE
| ID: mdl-19485532
ABSTRACT
This article describes the design and fabrication of a microfluidic mixing system optimized for ultrasensitive optical measurements. Channels are replica-molded in polydimethylsiloxane elastomer and sealed with fused-silica coverglass. The resulting devices have broad chemical compatibility and extremely low fluorescence background, enabling measurements of individual molecules under well-characterized nonequilibrium conditions. Fluid delivery and pressure connections are made using an interface that allows for rapid assembly, rapid sample exchange, and modular device replacement while providing access for high numerical aperture optics.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Analíticas Microfluídicas
Idioma:
En
Revista:
Rev Sci Instrum
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos