Critical determinants of hypothalamic appetitive neuropeptide development and expression: species considerations.
Front Neuroendocrinol
; 31(1): 16-31, 2010 Jan.
Article
em En
| MEDLINE
| ID: mdl-19822169
ABSTRACT
Over the last decade there has been a striking increase in the early onset of metabolic disease, including obesity and diabetes. The regulation of energy homeostasis is complex and involves the intricate integration of peripheral and central systems, including the hypothalamus. This review provides an overview of the development of brain circuitry involved in the regulation of energy homeostasis as well as recent findings related to the impact of both prenatal and postnatal maternal environment on the development of these circuits. There is surprising evidence that both overnutrition and undernutrition impact the development of these circuits in a similar manner as well as having similar consequences of increased obesity and diabetes later in life. There is also a special focus on relevant species differences in the development of hypothalamic circuits. A deeper understanding of the mechanisms involved in the development of brain circuitry is needed to fully understand how the nutritional and/or maternal environments impact the functional circuitry as well as the behavior and physiological outcomes.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeos
/
Hipotálamo
/
Fenômenos Fisiológicos da Nutrição
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Adult
/
Animals
/
Child
/
Child, preschool
/
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Front Neuroendocrinol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos