Prohepcidin concentrations and erythroid progenitors in cord blood of appropriate versus small for gestational age neonates.
J Perinatol
; 30(6): 396-8, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-19890342
ABSTRACT
OBJECTIVE:
Prohepcidin (Pro-Hep), synthesized in the liver, is the prohormone of hepcidin (Hep), which reduces iron absorption in the gut; its synthesis is enhanced by inflammation and is reduced during hypoxia. We aimed to study the hypothesis that infants born small for gestational age (SGA) have reduced cord blood concentrations of Pro-Hep. STUDYDESIGN:
Cord blood was collected from 20 SGA (term and near term >35 week gestation) infants and 20 appropriate for gestational age (AGA) controls. We excluded infants exposed to maternal chronic diseases, smoking, diabetes, alcohol or drug use. Both groups had a 1 min Apgar score above or equal to 7 and had normal cord blood pH (above 7.25). ELISA was used to determine serum concentrations of Pro-Hep and erythropoietin (EPO). Circulating CD71(+)/CD45(-)/SSC(low) cells were measured by flow cytometry as an index of erythroid progenitors.RESULT:
There were no significant differences between groups in terms of hemoglobin concentrations, and Pro-Hep. In contrast, EPO levels and circulating CD71(+)/CD45(-)/SSC(low) erythroid progenitors were significantly higher in the SGA group. These differences remained significant even after controlling for gestational age and gravidity.CONCLUSION:
Contrary to EPO upregulation during intrauterine growth restriction (IUGR), and higher concentrations of circulating erythroid progenitors, Pro-Hep concentration is not affected by IUGR.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de Proteínas
/
Recém-Nascido Pequeno para a Idade Gestacional
/
Eritropoetina
/
Peptídeos Catiônicos Antimicrobianos
/
Contagem de Eritrócitos
/
Sangue Fetal
/
Retardo do Crescimento Fetal
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
J Perinatol
Assunto da revista:
PERINATOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Israel