Three-dimensional simulations of multidetector point-focusing SPECT imaging.
J Nucl Med
; 32(2): 333-8, 1991 Feb.
Article
em En
| MEDLINE
| ID: mdl-1992040
ABSTRACT
We have applied an efficient algorithm for mathematically simulating the three-dimensional (3-D) response of a SPECT imaging system with a depth-dependent 3-D point spread function (3-DPSF). The input object whose reconstructed image is to be simulated is restricted to a binary map; more complex objects may be treated as linear combinations of binary maps. The 3-D convolution reduces to a sequence of additions of a 3-D line spread function (3-DLSF), appropriately translated, to the 3-D response. We have simulated the projection data from a multidetector SPECT system with point-focusing collimators. The simulated projection data were then reconstructed using the manufacturer's software. The objects simulated included simple geometrical solids such as spheres and cylinders, as well as the distribution of muscarinic cholinergic receptors in a realistic brain slice. The results of these simulations indicate the existence of significant qualitative and quantitative artifacts in reconstructed human brain images.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Simulação por Computador
/
Processamento de Imagem Assistida por Computador
/
Tomografia Computadorizada de Emissão de Fóton Único
Tipo de estudo:
Qualitative_research
Idioma:
En
Revista:
J Nucl Med
Ano de publicação:
1991
Tipo de documento:
Article