Age-related defects in the cytoskeleton signaling pathways of CD4 T cells.
Ageing Res Rev
; 10(1): 26-34, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-19941976
ABSTRACT
It has been postulated that the cytoskeleton controls many aspects of T cell function, including activation, proliferation and apoptosis. Recent advances in our understanding of F-actin polymerization and the Ezrin-Radixin-Moesin (ERM) family of cytoskeleton signal proteins have provided new insights into immunological synapse formation during T cell activation. During aging there is a significant decline of T cell function largely attributable to declines in activation of CD4 T cells and defects in the formation of the immunological synapse. Here we discuss recent progress in the understanding of how aging alters F-actin and ERM proteins in mouse CD4 T cells, and the implications of these changes for the T cell activation process.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
/
Envelhecimento
/
Linfócitos T CD4-Positivos
/
Transdução de Sinais
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Ageing Res Rev
Assunto da revista:
GERIATRIA
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos