Histidine decarboxylase gene expression in rat fundus is regulated by gastrin.
FEBS Lett
; 281(1-2): 20-2, 1991 Apr 09.
Article
em En
| MEDLINE
| ID: mdl-2015894
ABSTRACT
The conversion of histidine to histamine by histidine decarboxylase (HDC) is of central importance in the control of vertebrate acid secretion. We have used PCR-generated probes to study the regulation of HDC gene expression in rat fundic mucosa. When circulating gastrin levels were lowered by fasting or elevated by treatment with omeprazole, there were parallel changes in HDC mRNA abundance. However, when animals with elevated gastrin levels were concurrently treated with the gastrin/CCK-B receptor antagonist PD 134308, HDC mRNA levels were not increased. These data are consistent with the hypothesis that HDC gene expression is regulated by gastrin, over the physiological range of circulating hormone concentrations.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Estômago
/
Gastrinas
/
Regulação Enzimológica da Expressão Gênica
/
Histidina Descarboxilase
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido