Ionic topochemical tuned biosensor interface.
Langmuir
; 26(11): 9088-93, 2010 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-20180587
Two new hydrophilic, poly(ethylene glycol) (PEG)-based redox copolymers bearing electrochemically active ferrocene (Fc) and thiol/disulfide anchoring functionalities were synthesized. These copolymers are shown to adsorb on gold surfaces causing polymeric self-assembled monolayers (pSAMs) that possess triple functions: "redox-active", "ionic-tunable", and "bio-inert". Both immobilized polymers showed redox potentials at +400 mV (Ag|AgCl), and facilitate the electrocatalytical oxidation of NADH. Additionally, interfacial architecture of the polymers is affected by an increase in Ca(2+) concentration, which leads to an amplification of the electrochemical response. The electrode current, measured for NADH-oxidation, increased by 80% after addition of 10 mM Ca(2+) ions. Considering the Ca(2+) influence on the heterogeneous electron transfer a structural model of the immobilized polymers is proposed based on the strong chelating ability of noncyclic PEG moieties.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Técnicas Biossensoriais
Idioma:
En
Revista:
Langmuir
Assunto da revista:
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha