Pruritus: control of itch in patients undergoing dialysis.
Skin Therapy Lett
; 15(2): 1-5, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20361169
ABSTRACT
Chronic kidney disease (CKD)-associated pruritus is a significant clinical symptom affecting more than 50% of patients on hemodialysis. Restricted by the availability of effective therapeutic options, the management of CKD-associated pruritus remains a treatment challenge. Evaluating research in this area is difficult, as most studies are not comparable due to differing methodologies and study designs, limited number of patients, and the lack of standardized measures. The most frequently used therapy is UVB phototherapy, eliciting favorable responses in most patients. Newer approaches, such as treatment with the m-opiod-receptor antagonist, naltrexone, have yielded conflicting results. The use of the k-opioid-receptor-agonist, nalfurafine, appears to be partially effective in relieving CKD-associated pruritus, as shown by a meta-analysis of 2 clinical trials. Promising results have been obtained by treatment with the anticonvulsant gabapentin. CKD-associated pruritus is thought to be mediated by a proinflammatory state, which explains why immunomodulating drugs (e.g., thalidomide, tacrolimus, and pentoxiphylline) are effective in some patients. Treatment of CKD-associated pruritus should be undertaken according to individual benefit-risk ratio assessments.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prurido
/
Falência Renal Crônica
/
Antipruriginosos
Tipo de estudo:
Etiology_studies
Limite:
Humans
Idioma:
En
Revista:
Skin Therapy Lett
Assunto da revista:
DERMATOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha