Management of radiation-induced sarcomas in a tertiary referral centre: a review of 25 cases.
Breast
; 19(5): 424-7, 2010 Oct.
Article
em En
| MEDLINE
| ID: mdl-20542697
ABSTRACT
INTRODUCTION:
Radiation-induced sarcomas are a rare and late complication of radiotherapy for breast carcinoma which often have poor prognosis.METHODS:
This study is a retrospective review of 25 patients referred to a regional sarcoma unit between 1978 and 2009.RESULTS:
Radiation-induced sarcoma following the diagnosis and treatment of breast cancer occurred after a mean period of 156 months. Anatomical sites involved were the breast, chest wall, clavicle, scapula, humerus and axilla. Twenty one patients had wide local excision followed by chest wall reconstruction, latissimus dorsi flap cover or limb amputation. The estimated five years survival following the diagnosis of the radiation-induced sarcoma was 27% and the local recurrence rate 52%.CONCLUSION:
Radiation-induced sarcoma following breast cancer has high local recurrence rate and poor prognosis. They should be managed in a multi-disciplinary setting. Long-term follow-up of patients treated with radiotherapy for breast cancer is therefore advisable.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sarcoma
/
Neoplasias da Mama
/
Segunda Neoplasia Primária
/
Neoplasias Induzidas por Radiação
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Breast
Assunto da revista:
ENDOCRINOLOGIA
/
NEOPLASIAS
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido