Lower blood pressure associated with higher mortality in elderly diabetic patients (ZODIAC-12).
Age Ageing
; 39(5): 603-9, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20621928
ABSTRACT
OBJECTIVE:
to investigate the relationship between blood pressure over time and mortality in elderly patients with type 2 diabetes mellitus (T2DM).DESIGN:
prospective observational cohort study.SETTING:
primary care, Zwolle, The Netherlands.SUBJECTS:
patients with T2DM aged 60 years and older (n = 881). The cohort was divided into two age categories 60-75 years and older than 75 years.METHODS:
updated means for systolic, diastolic and pulse pressures were calculated after a median follow-up time of 9.8 years. These values were used as time-dependent covariates in a Cox proportional hazard model. Main outcome measures were all-cause and cardiovascular mortality.RESULTS:
all of the blood pressure measures were inversely related to all-cause mortality in elderly diabetic patients (>75 years). Furthermore, these relationships were specifically found in elderly patients treated with antihypertensive medication at baseline. A decrease of 10 mm Hg in systolic blood pressure, diastolic blood pressure and pulse pressure led to a mortality increase of 22% [95% confidence interval (95% CI) 13-31%], 30% [95% CI 13%-46%] and 22% [95% CI 11%-33%], respectively. In the low age group (60-75 years), no relationship was found between blood pressure and mortality.CONCLUSIONS:
blood pressure is a marker for mortality in elderly T2DM patients; however, the relationship is inverse.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Pressão Sanguínea
/
Diabetes Mellitus Tipo 2
/
Hipertensão
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
Europa
Idioma:
En
Revista:
Age Ageing
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Holanda