Changes to synaptic ultrastructure in field CA1 of the rat hippocampus following intracerebroventricular injection of kainic acid.
Neuroscience
; 40(3): 687-99, 1991.
Article
em En
| MEDLINE
| ID: mdl-2062438
ABSTRACT
To assess the nature and extent of ultrastructural damage due to low unilateral intracerebroventricular doses of kainic acid, treated rats were killed at survival times from 8 h to 14 weeks. Degenerative changes in field CA1 of the hippocampus included dark profiles (often presynaptic), lucent areas enveloping axonic or dendritic elements, damaged myelin sheaths, and enlarged glial profiles. The effect of kainic acid ipsilaterally was maximal at three days but also apparent up to 14 weeks. Contralateral CA1 showed similar though less extensive abnormalities. These observations suggest that, despite rapid synaptic replacement (Nadler et al., Brain Res. 191, 387-403, 1980), long-term electrophysiological abnormalities (Cornish and Wheal, Neuroscience 28, 563-571, 1989) may stem not only from inappropriate reactive synaptogenesis but also from a continuing state of neuronal degeneration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinapses
/
Hipocampo
/
Ácido Caínico
Limite:
Animals
Idioma:
En
Revista:
Neuroscience
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Reino Unido