Methylenehydrofolate reductase (C677T) polymorphism and large artery ischemic stroke subtypes.
Acta Neurol Scand
; 123(2): 105-10, 2011 Feb.
Article
em En
| MEDLINE
| ID: mdl-20637011
ABSTRACT
BACKGROUND:
The role for the methylenetetrahydrofolate reductase C677T gene variants in the risk of ischemic stroke is controversial.METHOD:
This first case-control study including 91 cases affected by ischemic stroke and 182 controls matched for age, sex, and same area was conducted in Casablanca, Morocco. Allele and genotype frequency were characterized by using PCR followed by HinfI enzymatic digestion.RESULTS:
We found no statistic association of T allele carriers genetic factors with stroke; odds ratio, 1.1; 95% confidence interval (CI), 0.59-2.04, P = 0.303. The results shown significant association of T allele carriers genetic factors with atherothrombotic subtype stroke (n = 42); odds ratio, 2.1; 95% CI 1.17-3.8; P = 0.012, and adjusted odds ratio of 6.5; 95% CI 1.86-23.1, P = 0.003, for TT genotype variant compared with CC wild genotype.CONCLUSION:
We suggested that MTHFR C677T variant may be a determinant of atherothrombotic event of ischemic stroke in Morocco.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Predisposição Genética para Doença
/
Acidente Vascular Cerebral
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Polimorfismo de Nucleotídeo Único
/
Metilenotetra-Hidrofolato Redutase (NADPH2)
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Adult
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Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Marrocos