Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts.

Saito, Shinichi; Takayama, Yoshiharu; Mizumachi, Koko; Suzuki, Chise

Saito, Shinichi; Takayama, Yoshiharu; Mizumachi, Koko; Suzuki, Chise.

Afiliação

Saito S; Functional Biomolecules Research Team, National Institute of Livestock and Grassland Science, 2 Ikenodai, Tsukuba, Ibaraki, 305-0901, Japan.

Biotechnol Lett ; 33(1): 33-9, 2011 Jan.

Article em En | MEDLINE | ID: mdl-20820878

ABSTRACT

ABSTRACT

Bovine lactoferrin (BLF) enhanced production of hyaluronan in normal human dermal fibroblasts. The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. The promoting effect of BLF was not observed for HAS1. In addition, COL1A1 transcription and collagen synthesis were enhanced by BLF. These observations suggest that BLF promotes wound healing by increasing hyaluronan and type-I collagen synthesis.

Assuntos

Fibroblastos/metabolismo; Ácido Hialurônico/biossíntese; Lactoferrina/metabolismo; Animais; Bovinos; Colágeno Tipo I/biossíntese; Cadeia alfa 1 do Colágeno Tipo I; Expressão Gênica; Glucuronosiltransferase/biossíntese; Humanos; Hialuronan Sintases; Regulação para Cima; Cicatrização

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fibroblastos / Ácido Hialurônico / Lactoferrina Limite: Animals / Humans Idioma: En Revista: Biotechnol Lett Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Japão

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