Lactoferrin promotes hyaluronan synthesis in human dermal fibroblasts.
Biotechnol Lett
; 33(1): 33-9, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20820878
ABSTRACT
Bovine lactoferrin (BLF) enhanced production of hyaluronan in normal human dermal fibroblasts. The elevation of hyaluronan was accompanied by elevation of HAS2 (hyaluronan synthase 2) mRNA transcription and HAS2 protein expression. The promoting effect of BLF was not observed for HAS1. In addition, COL1A1 transcription and collagen synthesis were enhanced by BLF. These observations suggest that BLF promotes wound healing by increasing hyaluronan and type-I collagen synthesis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fibroblastos
/
Ácido Hialurônico
/
Lactoferrina
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biotechnol Lett
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Japão