Regulation of FTO and FTM expression during human preadipocyte differentiation.
Horm Metab Res
; 43(1): 17-21, 2011 Jan.
Article
em En
| MEDLINE
| ID: mdl-20865646
ABSTRACT
In genome-wide association studies (GWAS), polymorphisms in the first intron of FTO were shown to be associated with body fat mass. However, the functional properties of FTO and its nearby gene FTM are largely unknown. We examined the expression of these genes in subcutaneous adipose tissue and in isolated preadipocytes of lean and obese women. In in vitro differentiated primary human preadipocytes and in SGBS preadipocytes we found a decline in FTO and FTM expression during adipogenic differentiation. When investigating the hormonal regulation of FTO and FTM in adipocytes, insulin was identified as a key factor regulating FTM expression indicating a potential role of FTM in insulin regulated adipocyte metabolism.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas
/
Diferenciação Celular
/
Regulação da Expressão Gênica
/
Adipócitos
Tipo de estudo:
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Horm Metab Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Alemanha