Independence of benzodiazepine and opiate action in the suppression of isolation distress in rat pups.
Behav Neurosci
; 104(1): 160-6, 1990 Feb.
Article
em En
| MEDLINE
| ID: mdl-2107826
ABSTRACT
To determine whether benzodiazepines (BDZs) quiet isolation distress in 10-day-old rat pups by causing a release of endogenous opioids, a blockade of the effects of chlordiazepoxide (CDP) by the opiate antagonist naltrexone (NLX) was sought. Nonsedating doses of morphine (MOR) (0.125 mg/kg) and CDP (2.0 mg/kg) were equally effective in reducing ultrasonic vocalizations and other indices of isolation distress. Appropriate blocking agents NLX, (0.5 mg/kg) against MOR and Ro 15-1788 (4.0 mg/kg) against CDP returned distress measures to levels of saline-treated rat pups. However, NLX failed to reverse the quieting effects of CDP. If CDP potentiates endogenous opioid release, then NLX should block the CDP effect. A higher dose of CDP did not reveal a release of endogenous opioids, and a higher dose of NLX did not antagonize CDP. The quieting effects of BDZs on isolation distress do not appear to be mediated by the opiate system.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Nível de Alerta
/
Isolamento Social
/
Vocalização Animal
/
Clordiazepóxido
/
Morfina
Limite:
Animals
Idioma:
En
Revista:
Behav Neurosci
Ano de publicação:
1990
Tipo de documento:
Article