Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN.
Analyst
; 136(6): 1103-5, 2011 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-21221467
ABSTRACT
Controlled H-aggregation of single Pc-labeled oligonucleotides is utilized as a fluorescence quenching system to discern changes in enzyme activity for the discovery of inhibitors for Long Interspersed Element 1 endonuclease (L1-EN), which is involved in genome instability and implicated in many different diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espectroscopia de Luz Próxima ao Infravermelho
/
Elementos Nucleotídeos Longos e Dispersos
/
Endodesoxirribonucleases
/
Indóis
Idioma:
En
Revista:
Analyst
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos