Th17: contributors to allograft rejection and a barrier to the induction of transplantation tolerance?
Transplantation
; 91(9): 939-45, 2011 May 15.
Article
em En
| MEDLINE
| ID: mdl-21378605
ABSTRACT
T helper (Th) type 17 cells are a recently described CD4 T-cell subset that may contribute to allograft rejection and act as a barrier to the induction of transplant tolerance. This review examines the involvement of Th17 cells in transplant rejection, how immunosuppressive medication may affect their induction and maintenance and the potential plasticity of developing Th17 cells. It also addresses the complex interplay between the Th17 and regulatory T-cell developmental pathways and the susceptibility of Th17 cells to regulation. Despite accumulating evidence, the precise impact of Th17 cells on transplant rejection and the induction of tolerance require further clarification.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tolerância ao Transplante
/
Células Th17
/
Rejeição de Enxerto
Tipo de estudo:
Etiology_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Transplantation
Ano de publicação:
2011
Tipo de documento:
Article