The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases.
Clin Exp Immunol
; 164(2): 145-57, 2011 May.
Article
em En
| MEDLINE
| ID: mdl-21401577
ABSTRACT
Autoimmune diseases are characterized by the body's ability to mount immune attacks on self. This results from recognition of self-proteins and leads to organ damage due to increased production of pathogenic inflammatory molecules and autoantibodies. Over the years, several new potential therapeutic targets have been identified in autoimmune diseases, notable among which are members of the tumour necrosis factor (TNF) superfamily. Here, we review the evidence that certain key members of this superfamily can augment/suppress autoimmune diseases.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Autoimunes
/
Fator de Necrose Tumoral alfa
/
Receptores do Fator de Necrose Tumoral
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Clin Exp Immunol
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Estados Unidos