Application of the bridgehead fragments for the design of conformationally restricted melatonin analogues.
Bioorg Chem
; 39(2): 67-72, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21419469
ABSTRACT
Conformationally constrained analogues of the hormone melatonin with a side chain incorporated into the bicyclic bridgehead core were synthesized based on the homology modeling and molecular docking studies performed for the MT(2) melatonin receptor. The methoxy-indole derivative fused with exo-N-acetamino-substituted bicyclo[2.2.2]octane was found to possess nanomolar MT(2) receptor affinity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Melatonina
Idioma:
En
Revista:
Bioorg Chem
Ano de publicação:
2011
Tipo de documento:
Article