Reanalysis of coreceptor tropism in HIV-1-infected adults using a phenotypic assay with enhanced sensitivity.

Wilkin, Timothy J; Goetz, Mathew Bidwell; Leduc, Robert; Skowron, Gail; Su, Zhaohui; Chan, Ellen S; Heera, Jayyant; Chapman, Doug; Spritzler, John; Reeves, Jacqueline D; Gulick, Roy M; Coakley, Eoin

Wilkin, Timothy J; Goetz, Mathew Bidwell; Leduc, Robert; Skowron, Gail; Su, Zhaohui; Chan, Ellen S; Heera, Jayyant; Chapman, Doug; Spritzler, John; Reeves, Jacqueline D; Gulick, Roy M; Coakley, Eoin.

Afiliação

Wilkin TJ; Division of Infectious Disease, Weill Cornell Medical College, New York, New York 10011, USA. tiw2001@med.cornell.edu

Clin Infect Dis ; 52(7): 925-8, 2011 Apr 01.

Article em En | MEDLINE | ID: mdl-21427401

ABSTRACT

ABSTRACT

The enhanced-sensitivity Trofile assay (TF-ES; Monogram Biosciences) was used to retest coreceptor tropism samples from 4 different cohorts of HIV-1-infected patients. Nine percent to 26% of patients with CCR5-tropic virus by the original Trofile assay had CXCR4-using virus by TF-ES. Lower CD4 cell counts were associated with CXCR4-using virus in all cohorts.

Assuntos

Infecções por HIV/virologia; HIV-1/fisiologia; Receptores de HIV/metabolismo; Tropismo Viral; Virologia/métodos; Ligação Viral; Adulto; Humanos; Receptores CCR5/metabolismo; Receptores CXCR4/metabolismo

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Virologia / Infecções por HIV / Receptores de HIV / HIV-1 / Ligação Viral / Tropismo Viral Tipo de estudo: Diagnostic_studies Limite: Adult / Humans Idioma: En Revista: Clin Infect Dis Assunto da revista: DOENCAS TRANSMISSIVEIS Ano de publicação: 2011 Tipo de documento: Article País de afiliação: Estados Unidos

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