The role of iNOS and PHOX in periapical bone resorption.
J Dent Res
; 90(4): 495-500, 2011 Apr.
Article
em En
| MEDLINE
| ID: mdl-21441224
ABSTRACT
Nitric oxide (NO) and reactive oxygen species (ROS) are key molecules in resistance to pathogens. Little is known about their role in pathogenesis of periapical lesions. To address this issue, we induced periapical lesions in mice lacking nitric oxide synthase (iNOS(-/-)) or phagocyte oxidase (PHOX(-/-)). iNOS(-/-) mice expressed higher levels of IL-1ß, TNF-α, RANK, RANKL, and MCP-1 than C57BL/6 and PHOX(-/-). Apical thickening of the periodontal ligament was also greater in iNOS(-/-) compared with other groups. Interestingly, ROS production did not interfere in periapical lesion progression, but seemed to be essential for the appearance of multinucleated TRAP-positive cells. Thus, periapical lesion progression in iNOS(-/-) was associated with an imbalance of pro-inflammatory cytokines (IL-1ß and TNF-α), bone-resorptive modulators (RANK and RANKL), and MCP-1. We conclude that NO, but not ROS, controls progression of bone resorption in a murine experimental model of apical periodontitis.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Periodontite Periapical
/
Fagócitos
/
Perda do Osso Alveolar
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NADPH Oxidases
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Óxido Nítrico Sintase Tipo II
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Revista:
J Dent Res
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
Brasil