Ginsenoside Rg3 inhibits CXCR4 expression and related migrations in a breast cancer cell line.
Int J Clin Oncol
; 16(5): 519-23, 2011 Oct.
Article
em En
| MEDLINE
| ID: mdl-21455623
ABSTRACT
BACKGROUND:
Ginsenoside Rg3 is an extract from the natural product ginseng. Previous studies have linked Rg3 with anti-metastasis of cancer in vivo and in vitro. CXC receptor 4 (CXCR4) is a vital molecule in migration and homing of cancer to the docking regions.METHODS:
In this study, the effects of Rg3 on CXCR4 expression were investigated in a breast cancer cell line. Immunohistochemistry, chemotaxis and wound healing mobility assays were performed in cultured MDA-MB-231 cells.RESULTS:
At a dosage without obvious cytotoxicity, Rg3 treatment elicits a weak CXCR4 stain color, decreases the number of migrated cells in CXCL12-elicited chemotaxis and reduces the width of the scar in wound healing.CONCLUSION:
This work suggests that Rg3 is a new CXCR4 inhibitor from a natural product.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Medicamentos de Ervas Chinesas
/
Movimento Celular
/
Receptores CXCR4
/
Ginsenosídeos
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Antineoplásicos
Limite:
Female
/
Humans
Idioma:
En
Revista:
Int J Clin Oncol
Assunto da revista:
NEOPLASIAS
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China