Pseudogene-derived small interference RNAs regulate gene expression in African Trypanosoma brucei.
Proc Natl Acad Sci U S A
; 108(20): 8345-50, 2011 May 17.
Article
em En
| MEDLINE
| ID: mdl-21531904
ABSTRACT
Pseudogenes have been shown to acquire unique regulatory roles from more and more organisms. We report the observation of a cluster of siRNAs derived from pseudogenes of African Trypanosoma brucei using high through-put analysis. We show that these pseudogene-derived siRNAs suppress gene expression through RNA interference. The discovery that siRNAs may originate from pseudogenes and regulate gene expression in a unicellular eukaryote provides insights into the functional roles of pseudogenes and into the origin of noncoding small RNAs.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trypanosoma brucei brucei
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Pseudogenes
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Regulação da Expressão Gênica
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RNA Interferente Pequeno
Idioma:
En
Revista:
Proc Natl Acad Sci U S A
Ano de publicação:
2011
Tipo de documento:
Article