Changes in lifestyle improve body composition, thyroid function, and structure in obese children.
J Endocrinol Invest
; 35(3): 281-5, 2012 Mar.
Article
em En
| MEDLINE
| ID: mdl-21623157
ABSTRACT
BACKGROUND:
Alterations in thyroid function and structure have been reported in obesity. Function reverses to normal after weight loss, but nothing is known about structure.AIM:
To evaluate the effect of weight loss on thyroid function and structure in obese children. SUBJECTS ANDMETHODS:
The study was conducted in 72 overweight and obese children. Measurement of free T(3) (fT(3)), free T4 (fT(4)), TSH, antithyroid- antibodies and a thyroid ultrasound was performed at the beginning (phase 1) and after a period of 1.8±1.0 yr of lifestyle intervention (phase 2).RESULTS:
Height SD score (SDS), body mass index SDS, total fat mass did not change from phase 1 to phase 2. Percentage of fat free mass decreased significantly (p<0.05). Waist/height ratio decreased (0.6±0.1 vs 0.5±0.1; p<0.05) as well as waist/hip ratio (0.9±0.1 vs 0.8±0.1; p<0.05). In phase 1, TSH was 2.8±1.7 mU/l; in phase 2, it was 2.2±0.9 mU/l (p<0.05); 17.2% of children showed a TSH level above the normal range (3.6 mU/l) in phase 1, and 6.2% in phase 2 (p<0.05). fT(4) was 10.8±2.2 pg/ml in phase 1 and 10.7±1.9 pg/ml in phase 2. fT(3) was 4.4±1.3 pg/ml (phase 1) and 3.9±1.1 pg/ml (phase 2) (p<0.05). Thyroid volume was -0.5±0.8 SDS (phase 1) and -0.5±1 SDS (phase 2). A non-significant improvement in thyroid structure was observed.CONCLUSIONS:
In conclusion, healthier lifestyle improves body composition, thyroid function, and structure.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glândula Tireoide
/
Composição Corporal
/
Programas de Redução de Peso
/
Estilo de Vida
/
Obesidade
Tipo de estudo:
Evaluation_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
J Endocrinol Invest
Ano de publicação:
2012
Tipo de documento:
Article
País de afiliação:
Itália