[Existing problems and strategies in liposome-mediated nucleic acid delivery].
Yao Xue Xue Bao
; 46(3): 261-8, 2011 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-21626778
ABSTRACT
Liposome-mediated nucleic acid delivery has been a focus recently, but in the course of delivering nucleic acid, some hurdles seriously limit the nucleic acid exerting treatment effect. This review refers to a series of problems such as low blood stability, reticuloendothelial system absorption, the lower targeting of liposome and the restriction of endosomal escape which are suffered in liposome-mediated nucleic acid delivery; and gives a detail introduction of strategies such as PEGylation, ligand modification, photochemical internalization, the application of degradation liposome and membrane-lytic peptide, to overcome those problems.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polietilenoglicóis
/
Sistema Fagocitário Mononuclear
/
Ácidos Nucleicos
/
Lipossomos
Limite:
Animals
/
Humans
Idioma:
Zh
Revista:
Yao Xue Xue Bao
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China