Value of contrast-enhanced sonography with micro flow imaging in the diagnosis of prostate cancer.
J Clin Ultrasound
; 39(7): 371-7, 2011 Sep.
Article
em En
| MEDLINE
| ID: mdl-21656780
ABSTRACT
BACKGROUND:
To evaluate the effectiveness of contrast-enhanced sonographic micro flow imaging (MFI) in the diagnosis of prostate cancer.METHODS:
A total of 74 patients referred for prostate biopsy were prospectively evaluated with MFI. The abnormalities were categorized into four patterns pattern 1 indistinct separation between the inner and outer gland; pattern 2 asymmetrical or focally increased enhancement in the outer gland; pattern 3 enhancement with focal defect; pattern 4 enhancement in the outer gland equal to that of the inner gland. The findings were correlated with Gleason scores.RESULTS:
Prostate cancer was detected in 264 sites in 41 patients. The sensitivity, specificity, accuracy, and positive and negative predictive values for MFI were 81.1%, 84.3%, 83.3%, 68.6%, and 91.3%, respectively. Positive predictive values for the four patterns were 46.0 (pattern 1), 53.6 (pattern 2), 94.3 (pattern 3), and 95.4 (pattern 4). Gleason scores of cancers with patterns 3 (7.09) or 4 (7.51) were significantly higher than those with patterns 1 (6.17) or 2 (6.59) (p = 0.001, p = 0.005, p < 0.001, p < 0.001).CONCLUSIONS:
Some MFI patterns had high positive predictive values and were associated with more aggressive cancers. This could be used to reduce the number of biopsy sites and detect clinically significant cancers.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Aumento da Imagem
/
Antígeno Prostático Específico
/
Endossonografia
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
J Clin Ultrasound
Ano de publicação:
2011
Tipo de documento:
Article