Total synthesis of landomycin A, a potent antitumor angucycline antibiotic.
J Am Chem Soc
; 133(32): 12433-5, 2011 Aug 17.
Article
em En
| MEDLINE
| ID: mdl-21780843
ABSTRACT
The first total synthesis of landomycin A, the longest and most potent antitumor angucycline antibiotic, has been achieved in 63 steps and 0.34% overall yield starting from 2,5-dihydroxybenzoic acid, 3,5-dimethylphenol, triacetyl d-glucal, and d-xylose, with a convergent linear sequence of 21 steps.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aminoglicosídeos
/
Antibióticos Antineoplásicos
Idioma:
En
Revista:
J Am Chem Soc
Ano de publicação:
2011
Tipo de documento:
Article
País de afiliação:
China